Research and Publications

research and publications

A comparison of the effectiveness of topical ac-11® plus sunscreen and sunscreen alone in protecting volunteers from sunlight-induced erythema (in house study 2005)
A review of DNA repair and possible DNA-repair adjuvants and selected natural antioxidants, (Dermatology On-line Journal, Noah Scheinfeld M.D., J.D. 2006)
A water-soluble extract from Uncaria tomentosa (Cat’s Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin (Mammone, Akesson, Gan, Giampapa and Pero 2006)
The repair of CPD’s in cell culture over 24 hours using antibodies against CPD (AGI Dermatics Technical Report 2004)
Topical ac-11® abates actinic keratosis and early squamous cell cancers in hairless mice exposed to UVA radiation Noah Scheinfeld, Dermatology ON-Line (Mentor, Etemadi, Patta, Scheinfeld 2015)

An active ingredient of Cat’s Claw water extracts Identification and efficacy of quinic acid 2005
An eight-week clinical study to evaluate the efficacy of a regimen of topical products on skin condition, Osmosis LLC, Ben Johnson MD (Catalyst ac-11® 2015)
DNA repair adjuvants The role of ac-11®, Dimercine, and Selenium in enhancing health and preventing skin cancer, Noah Scheinfeld M. Dl, J.D. 2006)
Effects of C-Med 100 on sunburn cell formation in Living Skin Cell Equivalents (Estee Lauder in house study 2002)
Protective and preventive activity of ac-11 on human explants after UV irradiation
The effectiveness of topical ac-11® in protecting against carcinogenesis in hairless mice exposed to repeated doses of solar-simulating radiation (In house study 2005)

BIO-EC Protection and preventive activity of ac-11® after UV irradiation and anti-aging activity on human skin explants maintained in survival (2008)
Carboxy alkyl esters of Uncaria tomentosa augment recovery of sensorineural functions following noise injury 2011
C-Med 100®, hot water extract of Uncaria tomentosa prolongs lymphocyte survival in vivo 2003
Comparison of a Broad Spectrum Anti Aging Nutritional Supplement with and without the Addition of a DNA Repair Enhancing Cat’s Claw Extract 2002
Dietary Quinic Acid Supplied as a Nutritional Supplement AIO + ac-11 leads to Induction of Micromolar Levels of nicotinamide and Tryptophan in the Urine 2010
DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study 2001
Enhanced DNA repair, immune function and reduced toxicity of ac-11® (CMED-100®), a novel aqueous extract from Uncaria tomentosa 1999
Formulation and in vitro,in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements 2005

In Vivo Treatment of Humans with Quinic Acid Enhances DNA Repair and Reduces the Influence of Lifestyle Factors on Risk to Disease 2009
Introduction of Apoptosis and Inhibition of Proliferation in Human Tumor Cells Treated with Extracts of Uncaria tomentosa 1998
Effect of AC-11® on 5 major Cytochrome P450 enzymes (biochemical assays)
Neuroprotective effects of aqueous extracts of Uncaria tomentosa Insights from 6 OHDA induced cell damage and transgenic Caenorhabditis elegans model 2013
Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncara tomentosa, C-Med-100® 2001
Preservation of Neural Sensitivity After Noise Induced Suppression of Sensory Function 2016
Protectagen® (with ac-11®) Powerful Botanical Support for Inflammation, DNA Repair, Immune Function and Gastrointestinal Healing 2010
Reduced Phosphorylation of Histone Variant H2Ax in the Organ of Corti is associated with Otoprotection from Noise Injury 2013
Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa 2000
Dynamic Compartmentalization of DNA Repair Proteins Within Spiral Ganglion Neurons in Response to Noise Stress 2012